Thermo Fisher Scientific Catenin alpha-1 Recombinant Rabbit Monoclonal Antibody (ARC0348)
Recombinant rabbit monoclonal antibody against Catenin alpha-1 (ARC0348). Suitable for WB and ELISA in human, mouse, and rat. High specificity and affinity purified. Supplied in PBS with glycerol and BSA. For research use only.
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- MA535193
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0348 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human alpha-Catenin (P35221) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.27 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849097 |
Product Specific Information
Immunogen sequence:
MTAVHAGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK KRGRSKKAHV LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVEDVRKQ
Target Information
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex linked to the actin filament network, which is essential for cadherin-mediated cell adhesion. Can associate with both E- and N-cadherins. Initially believed to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions, but later shown not to bind F-actin when in complex form. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex. Plays a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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