Thermo Fisher Scientific Phospho-Torc1 (Ser151) Polyclonal Antibody
Phospho-Torc1 (Ser151) 폴리클로날 항체로, CREB1 전사 활성 조절 연구에 사용됩니다. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 적합하며, Rabbit IgG 기반으로 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human Torc1 around the phosphorylation site of Ser151 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator in the SIK/TORC signaling pathway, being active when dephosphorylated and acting independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4 and regulates the expression of CREB-activated genes such as the steroidogenic gene StAR. Potent coactivator of PGC1α and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, it is involved in late-phase long-term potentiation (L-LTP) maintenance and may be required for dendritic growth of developing cortical neurons. In concert with SIK1, it regulates light-induced entrainment of the circadian clock by coactivating CREB-mediated transcription of PER1.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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