Thermo Fisher Scientific SCN9A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Predicted to react with Human samples.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarities, including two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.

There are three homologous isoforms of ENaC (alpha, beta, and gamma). ENaC in the kidney, lung, and colon plays a key role in trans-epithelial sodium and fluid balance, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure. ENaC is also regulated partly through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel.

Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC lead to pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.