Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody

Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
FPKSRIVRSL MPFSPYEPLN FHAMFQPFLE MIHEAQQAMD IHFHSPAFQH PPTEFIREGD DDRTVCREIR HNSTGCLRMK DQCDKCREIL SVDCSTNNPS QAKLRRELDE SLQVAERLTR KYNELLKSYQ WKMLNTSSLL EQLNEQFNWV SRLANLTQGE DQYYLRVTTV ASHTSDSDVP SGVTEVVVKL FDSDPITVTV PVEVSRKNPK FMETVAEKAL QEYRKKHREE

Positive Samples: A-549, HepG2, SW480, HeLa, 22Rv1, Mouse liver
Cellular Location: Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome, Mitochondrion membrane, Nucleus, Peripheral membrane protein, Chromaffin granule, Cytosol, Secretory vesicle

Target Information

Isoform 1 acts as an extracellular chaperone preventing aggregation of nonnative proteins and stress-induced aggregation of plasma proteins. It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants. Functions without ATP, maintaining proteins for refolding by other chaperones (e.g., HSPA8/HSC70). Secreted isoform protects cells against apoptosis and complement-mediated cytolysis. Intracellular isoforms promote ubiquitination and proteasomal degradation via SCF E3 ubiquitin ligase complexes, modulate NF-κB activity, and regulate apoptosis and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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