Thermo Fisher Scientific CD147 (soluble) Monoclonal Antibody (MEM-M6/1), PE
인간 CD147 단백질을 인식하는 고특이성 Mouse IgG1 단클론 항체로, PE 형광체가 결합되어 Flow Cytometry에 최적화됨. 세포 표면 CD147 검출에 사용되며, 높은 결합 친화도와 안정적 형광 신호를 제공. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-M6/1 |
| Immunogen | Protein A-CR purified soluble recombinant form of CD147 (CD147Rg), consisting of the hinge region, CH2 and CH3 domains of human IgG1. CD147Rg is secreted as a dimer. |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156001 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- APC
- Biotin
- FITC
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes an extracellular epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50–60 kDa type I transmembrane glycoprotein expressed on leukocytes, red blood cells, platelets, and endothelial cells. It is not expressed by resting lymphocytes.
The antibody exhibits high affinity and binds effectively to unstimulated peripheral blood T cells.
Target Information
CD147 (also known as basigin, neurothelin, OX-47, 5A11, CE9, M6, EMMPRIN, extracellular matrix metalloproteinase inducer, TCSF) is a 50–60 kDa glycoprotein with multiple glycosylated forms. It is a plasma membrane protein involved in spermatogenesis, embryo implantation, neural network formation, and tumor progression.
CD147 is part of the immunoglobulin superfamily and is highly expressed in metabolically active cells such as lymphoblasts, inflammatory cells, brown adipocytes, and malignant tumor cells.
It facilitates cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases and regulates integrin functions, contributing to cell development, activation, fetal development, and retinal function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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