Thermo Fisher Scientific PDGFRA Monoclonal Antibody (16A1), Biotin
PDGFRA 단백질을 인식하는 Biotin 결합 단클론 항체로, 인간 시료에서 ICC/IF 및 유세포분석에 사용 가능. CD140a 외부 에피토프를 인식하며, 다양한 중간엽 유래 세포 연구에 적합. 액상 형태로 제공되며 4°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16A1 |
| Immunogen | CD140a-transfected NIH 3T3 cells (Target Family: PDGFRA (CD140a), UniProt ID: P16234-1, Antigen Range: 1–1089) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153280 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor. It is widely expressed on various mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in different tumor types.
Target Information
PDGFRA is a cell surface receptor tyrosine kinase that binds members of the platelet-derived growth factor family. These growth factors act as mitogens for cells of mesenchymal origin. The identity of the bound growth factor determines whether the functional receptor forms as a homodimer or heterodimer (alpha and beta chains). Knockout studies in mice indicate that the alpha receptor is essential for kidney development, as heterozygous mice exhibit defective kidney phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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