Thermo Fisher Scientific CD4 Monoclonal Antibody (OTI3E11), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV.
CD4 is primarily expressed in a subset of T-lymphocytes (T helper cells) and may also be found in monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 is detectable in thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut.
It facilitates T-cell activation via association with the T-cell receptor complex and protein tyrosine kinase Lck.
CD4 may also mediate neuronal damage in infectious and immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.