Thermo Fisher Scientific Phospho-CREB (Ser133) Monoclonal Antibody (C.744.2)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• Publications: [References not provided]

Product Specifications

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors.
Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1.
Although CREB binds DNA independent of its phosphorylation state, only the phosphorylated form functions as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds in the region of serine 133.
CREB participates in cellular processes such as synchronization of circadian rhythmicity, adipocyte differentiation, and learning and memory. In humans, the gene is located on the q arm of chromosome 2.
Diseases associated with CREB dysfunction include Alzheimer’s disease, histiocytoma, and soft tissue melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.