Thermo Fisher Scientific Emerin Monoclonal Antibody (MANEM1(5D10))
Emerin 단백질을 인식하는 Mouse IgG1 단일클론 항체로, 인간 및 토끼 시료에 반응합니다. Western blot(1:400–1:800) 및 Immunocytochemistry(1:4–1:25)에 적합하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 단백질 G 정제, 4°C 또는 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:400–1:800
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:4–1:25
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rabbit |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MANEM1(5D10) |
| Immunogen | Recombinant Human Emerin (aa 1–188) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.1% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539459 |
Product Specific Information
- This antibody does not cross-react with mouse samples.
- The target has a predicted molecular weight of approximately 29 kDa.
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages.
Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981–1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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