Thermo Fisher Scientific IFN gamma Monoclonal Antibody (4S.B3), APC, eBioscience
인간 IFN-γ를 인식하는 4S.B3 단클론 항체로 APC 형광체 결합형입니다. Flow cytometry에서 0.125 µg/test로 사용 가능하며, 면역조절 및 항바이러스 연구에 적합합니다. 633–647 nm 적색 레이저에 적합하며, 액상 형태로 4°C 보관합니다.
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Thermo Fisher Scientific IFN gamma Monoclonal Antibody (4S.B3), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.125 µg/test | View 100 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4S.B3 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_469506 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 660
- Alexa Fluor 700
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 496 / 615 / 661 / 737 / 805
- Brilliant Violet 650
- eFluor 450 / 506 / 660
- FITC
- PE / PE-Cyanine7 / PE-eFluor 610
- PerCP-Cyanine5.5
- Custom conjugation available
Product Specific Information
The 4S.B3 monoclonal antibody reacts with interferon-gamma (IFNγ). Human IFNγ is a 17 kDa factor produced by activated T and NK cells, exhibiting antiviral and antiparasitic activity. In synergy with TNFα, it inhibits proliferation of normal and transformed cells and modulates immune responses across various cell types expressing IFNγ receptors. Glycosylation does not affect IFNγ biological activity.
Applications Reported: Intracellular flow cytometric analysis.
Applications Tested: Tested by flow cytometric analysis of activated human cells at ≤0.125 µg/test (100 µL final volume). Recommended to titrate for optimal performance.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IFNγ (Interferon gamma, Type II interferon) is a macrophage activation factor produced mainly by T lymphocytes and NK cells in response to antigens and cytokines. It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits. Human IFNγ is species-specific and does not cross-react with mouse IFNγ.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of MHC class I and II
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
Activation occurs via IFNγ receptor I and II, triggering the JAK-STAT pathway. Human IFNγ shares ~40% sequence homology with mouse IFNγ. Upregulated by IL2, FGF basic, EGF; downregulated by vitamin D3 or DMN. Mutations are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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