Thermo Fisher Scientific ITPKB Polyclonal Antibody
ITPKB 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot에 적합하며, 고순도(>95%) 항체입니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관됩니다. 연구용으로 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 205–250 of human ITPKB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2553838 |
Product Specific Information
This antibody detects endogenous protein at molecular weights of approximately 74 and 120 kDa.
Purity is greater than 95% by SDS-PAGE.
Target Information
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates intracellular calcium levels by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is thought to regulate calcium influx across the plasma membrane.
IP3K exists as three isoforms: IP3KA, IP3KB, and IP3KC.
- IP3KA: Highly expressed in rat brain and testis.
- IP3KB: Expressed in rat lung, thymus, testis, brain, and heart.
IP3K activity is stimulated by calmodulin and regulated via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin-dependent protein kinase II, mediating inositol phosphate signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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