Thermo Fisher Scientific Surface Lipoprotein p27 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• For extended storage, aliquot and freeze at -20°C or below.
• Avoid repeated freeze/thaw cycles.
• Centrifuge if solution is not clear at room temperature.
• Stable for several weeks at 4°C as undiluted liquid.
• Dilute only prior to immediate use.
• Specifically reactive to Borrelia burgdorferi p27 protein. Reactivity with p27 from other sources not determined.

Target Information

Surface Lipoprotein p27 of Borrelia burgdorferi is a surface-exposed lipoprotein expressed in the European strain B29 but not in the American strain B31.
Bacterial cell envelope proteins are key in host-parasite interactions such as adherence, invasion, and immune evasion.
p27 is a basic protein of 248 amino acids with a 17-residue leader sequence. The p27 gene is located on a ~55 kb linear plasmid.
Borrelia spirochetes are notable for numerous surface lipoproteins involved in Lyme disease and relapsing fever pathogenesis.
There is evidence that these lipoproteins are specifically targeted to the bacterial surface, though some may be retained in the periplasm via sequence-specific signals.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.