Thermo Fisher Scientific Phospho-MST2 (Ser316) Polyclonal Antibody
Phospho-MST2 (Ser316) 항체로 인간, 마우스, 랫트에서 인산화된 STK3 검출에 적합. Western blot에 1:500~1:2,000 희석으로 사용 가능. Hippo 신호 경로 연구 및 세포 사멸 관련 단백질 분석에 활용. 순차 크로마토그래피로 정제된 고품질 rabbit IgG 폴리클로날 항체.
- 카탈로그번호
- PA5105065
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STK3 (Accession Q13188), corresponding to amino acid residues around phosphorylated Ser316 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816538 |
Product Specific Information
Antibody detects endogenous levels of STK3 only when phosphorylated at Ser316.
Target Information
STK3 (MST2) is a STE kinase family member acting upstream of MAP kinase signaling pathways. It is activated by proapoptotic stimuli such as staurosporine and FAS ligand. STK3 functions as a stress-activated, pro-apoptotic kinase that, after caspase cleavage, enters the nucleus to induce chromatin condensation and DNA fragmentation.
It is a key component of the Hippo signaling pathway, which regulates organ size and tumor suppression by controlling proliferation and apoptosis. STK3/MST2 and STK4/MST1, in complex with SAV1, activate LATS1/2 and MOB1, leading to phosphorylation and inactivation of YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 prevents its nuclear translocation, thereby regulating genes involved in cell proliferation, death, and migration. STK3/MST2 and STK4/MST1 are critical for repressing hepatocyte proliferation and preventing tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-105065_MST2_Q13188-1_Rabbit.svg, PA5-105065_MST2_Q13188-1_Rabbit_PDP.jpeg)
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