Thermo Fisher Scientific MKP3 Recombinant Rabbit Monoclonal Antibody (SR39-09)
MKP3(DUSP6)을 인식하는 Recombinant Rabbit Monoclonal Antibody로, Western blot, IHC, ICC에 적합합니다. 높은 특이성과 재현성을 제공하며, lot 간 일관성이 우수합니다. 단백질 A로 정제된 액상 형태이며, 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SR39-09 |
| Immunogen | Recombinant protein within Human DUSP6 aa 325–381 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809282 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
DUSP6 (Dual Specificity Phosphatase 6) is part of the dual specificity phosphatase subfamily that inactivates target kinases by dephosphorylating phosphoserine/threonine and phosphotyrosine residues.
It negatively regulates MAP kinase family members (MAPK/ERK, SAPK/JNK, p38), which are involved in cellular proliferation and differentiation.
DUSP6 inactivates ERK2 and is expressed in various tissues, with highest levels in heart and pancreas. Unlike most other family members, it is localized in the cytoplasm. Two transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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