Thermo Fisher Scientific Phospho-EZH2 (Thr487) Polyclonal Antibody
EZH2 단백질의 Thr487 위치 인산화를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 정제 및 안정적 PBS/glycerol 저장. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-EZH2 (Thr487) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human EZH2 (Accession Q15910), corresponding to amino acid residues around phosphorylated Thr487 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817088 |
Product Specific Information
Antibody detects endogenous levels of EZH2 only when phosphorylated at Thr487.
Target Information
EZH2 (Histone-lysine N-methyltransferase) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes that maintain transcriptional repression of genes across cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play roles in hematopoietic and central nervous systems. Mutations affecting EZH2 can cause Weaver syndrome (WVS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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