Thermo Fisher Scientific Phospho-Zyxin (Ser143) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Zyxin only when phosphorylated at Ser143.

Target Information

Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and serve as sites for signal transduction complex assembly. It is a zinc-binding phosphoprotein concentrated at focal adhesions and along the actin cytoskeleton.
Zyxin contains an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signaling pathways, while the LIM domains are likely involved in protein–protein interactions.
Zyxin may function as a messenger in adhesion-stimulated gene expression changes and modulate actin bundle organization. Alternative splicing produces multiple transcript variants encoding the same isoform.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.