Thermo Fisher Scientific Phospho-PKN2 (Ser815) Polyclonal Antibody
PKN2 단백질의 Ser815 위치 인산화를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(파라핀)에서 검증됨. Human, Mouse, Rat 반응성. 1 mg/mL 농도, PBS/glycerol buffer에 보관. 세포주기 및 세포 이동 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PKN2 (Accession Q16513), corresponding to amino acid residues around phosphorylated Ser815 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817093 |
Product Specific Information
Antibody detects endogenous levels of PKN2 only when phosphorylated at Ser815.
Target Information
PKN2 (PRK2), a close relative of PKCs, regulates mitosis and cytokinesis exit. It plays roles in:
- Cell cycle progression and actin cytoskeleton assembly
- Cell migration, adhesion, and tumor invasion
- Transcription activation signaling processes
PKN2 phosphorylates CTTN in hyaluronan-induced astrocytes, reducing its actin association. It also phosphorylates HDAC5, impairing its import. As a direct RhoA target, PKN2 regulates apical junction formation in bronchial epithelial cells, G2/M phase progression, and cytokinesis via ECT2. It stimulates FYN kinase activity for keratinocyte differentiation, modulates epithelial bladder cell migration, inhibits Akt kinase activity, and mediates Rho-induced transcriptional activation via SRF. Additionally, it phosphorylates HCV NS5B to stimulate HCV RNA replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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