Thermo Fisher Scientific Cyclophilin B Polyclonal Antibody, Alexa Fluor 647

Thermo Fisher Scientific Cyclophilin B Polyclonal Antibody, Alexa Fluor 647

Applications and Tested Dilution

• Application: Immunocytochemistry (ICC/IF)
• Tested Dilution: 1–10 µg/mL

Species Reactivity

• Dog
• Human
• Mouse
• Rat

Host / Isotype

• Rabbit / IgG

Class

• Polyclonal

Type

• Antibody

Immunogen

Synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB.

Conjugate

Alexa Fluor™ 647

Excitation / Emission Max

650 / 671 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage Buffer

PBS, pH 7.4, with 1 mg/mL BSA

Contains

0.05% sodium azide

Storage Conditions

4°C, store in dark, DO NOT FREEZE

Shipping Conditions

• Ambient (domestic)
• Wet ice (international)

RRID

AB_2662702

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Product Specific Information

PA1027AA647 detects cyclophilin B (CyPB) in mouse, rat, canine, and human tissues.
The immunogen is a synthetic peptide corresponding to residues C(194)–E(208) of human CyPB, a sequence highly conserved across species.
The immunizing peptide (Cat. # PEP-058) is available for neutralization and control experiments.

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Target Information

Immunophilins are soluble cytosolic receptors binding immunosuppressants such as cyclosporin A (CsA) or FK506.

• FK506-binding proteins are termed FKBP, and CsA-binding proteins are cyclophilins (CyP).
• Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a Ca²⁺/calmodulin-dependent phosphatase involved in T-cell activation.
• Immunophilins act as peptidyl-prolyl cis-trans isomerases (PPIase), accelerating folding of proline-containing proteins.
  Their enzymatic activity is inhibited by the respective immunosuppressant compounds.

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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