Thermo Fisher Scientific GRAMD1A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol.
In lipid-poor conditions, localizes to the ER membrane, and in response to excess cholesterol in the PM, is recruited to the endoplasmic reticulum–plasma membrane contact sites (EPCS), mediated by the GRAM domain.
At the EPCS, the sterol-binding VASt/ASTER domain binds to cholesterol in the PM and facilitates its transfer from the PM to ER. May play a role in tumor progression. Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.