Thermo Fisher Scientific GRAMD1A Polyclonal Antibody
Rabbit polyclonal antibody against human GRAMD1A. Validated for WB and IP applications. Antigen between residues 300–350 of human GRAMD1A. Supplied as liquid, 1 mg/mL, purified by antigen affinity chromatography. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 300 to 350 of human GRAM Domain Containing 1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, serving as a molecular bridge for cholesterol transfer from the PM to the ER. Plays a crucial role in cholesterol homeostasis and can localize to the PM based on membrane cholesterol levels. In lipid-poor conditions, localizes to the ER membrane, and in response to excess cholesterol in the PM, is recruited to ER–PM contact sites mediated by the GRAM domain. At these sites, the sterol-binding VASt/ASTER domain binds to cholesterol in the PM and facilitates its transfer to the ER. May play a role in tumor progression and autophagy regulation, being required for autophagosome biogenesis. This function in autophagy depends on its cholesterol-transfer activity. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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