Thermo Fisher Scientific FKBP-135 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

FKBP15 (also known as FKBP133) is a member of the FK506-binding protein family, initially identified as immunophilins—targets for the immunosuppressant drugs FK506 and Rapamycin.
It is expressed in the developing nervous system and contains a domain similar to the Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif.
FKBP15 is distributed along axonal shafts and partially co-localizes with F-actin in growth cones of dorsal root ganglion neurons. Overexpression increases filopodia formation, suggesting its role in modulating growth cone behavior.
FKBP15 associates with both microtubules and actin filament systems, and RNAi-mediated disruption delays early endosome transport in HeLa cells, indicating involvement in endosomal transport.
At least three isoforms of FKBP15 are known to exist.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.