Thermo Fisher Scientific FKBP-135 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

FKBP15 (also known as FKBP133) is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins—targets for the immunosuppressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to the Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif.

FKBP15 is distributed along axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons. Overexpression of FKBP15 increases the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 associates with both microtubules and actin filaments, and RNAi-mediated disruption of its expression delays early endosome transport in HeLa cells, indicating its involvement in endosomal transport. At least three isoforms of FKBP15 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.