Thermo Fisher Scientific FKBP-135 Polyclonal Antibody
Human FKBP15 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 4°C 보관, 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 1–4 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1175 and the C-terminus (residue 1234) of human FK506-binding protein 135 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
FKBP15 (also known as FKBP133) is a member of the FK506-binding protein family, initially identified as immunophilins and targets for the immunosuppressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a WH1-like domain in addition to the FK506-binding motif. It is distributed along axonal shafts and co-localizes with F-actin in neuronal growth cones, influencing filopodia formation and growth cone behavior. FKBP15 associates with both microtubules and actin filaments, and its knockdown delays early endosome transport in HeLa cells, indicating a role in vesicular trafficking. At least three isoforms of FKBP15 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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