Thermo Fisher Scientific FKBP-135 Polyclonal Antibody
Human FKBP15 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IP에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 1 mg/mL 농도. 4°C에서 보관하며 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 960 and 1020 of human FK506-binding protein 135 (FKBP15, UniProt ID: Q5T1M5-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
FKBP15 (also known as FKBP133) is a member of the FK506-binding protein family, initially identified as immunophilins, targets for the immunosuppressant drugs FK506 and Rapamycin.
FKBP15 is expressed in the developing nervous system and contains a WH1 domain in addition to the FK506-binding motif. It is distributed along axonal shafts and co-localizes with F-actin in growth cones of dorsal root ganglion neurons. Overexpression increases filopodia formation, suggesting a role in growth cone modulation.
FKBP15 associates with both microtubules and actin filaments, and RNAi-mediated disruption delays early endosome transport in HeLa cells, indicating involvement in endosomal transport. At least three isoforms of FKBP15 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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