Thermo Fisher Scientific HMGN1 Polyclonal Antibody
HMGN1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS/glycerol 버퍼에 보존되며 -20°C에서 안정 저장 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HMGN1 (Accession P05114), corresponding to amino acid residues M1–D47 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903399 |
Product Specific Information
Antibody detects endogenous levels of total HMG14.
Target Information
The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements that alter the chromatin fiber structure and enhance transcription from chromatin templates. These proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of higher-order chromatin structures, facilitating access to the underlying DNA sequence. Clustering of architectural elements, such as HMG proteins and linker histone subtypes, into distinct domains may lead to structural and functional heterogeneity along the chromatin fiber. Additionally, HMG-14 and HMG-17 are constitutive components of mouse oocyte and embryonic chromatin, linking chromatin structure to embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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