Thermo Fisher Scientific Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232) Polyclonal Antibody
RSK1~4 인산화 부위(Ser221, Ser227, Ser218, Ser232)를 인식하는 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RSK1/2/3/4 around the phosphorylation site of Ser221/227/218/223 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903398 |
Target Information
The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases at the terminus of the ERK pathway. In humans, the RSK family consists of four isoforms (RSK1–4). These kinases contain two distinct catalytic domains activated sequentially by phosphorylation.
RSK regulates gene expression via phosphorylation of transcriptional regulators such as c-Fos, estrogen receptor, NFkappaB/IkappaB alpha, and CREB. ERK activates the C-terminal kinase of RSK, which in turn activates the N-terminal kinase. RSKs are located in both cytoplasm and nucleus, and upon activation, cytosolic RSK translocates to the nucleus to phosphorylate transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.