Thermo Fisher Scientific Phospho-TrkA (Tyr680, Tyr681) Polyclonal Antibody
TrkA 단백질의 Tyr680 및 Tyr681 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot과 IHC(P)에서 사용 가능. 고순도 액상 형태로 제공되며, PBS/glycerol buffer에 보존. 신경계 관련 신호전달 연구에 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NTRK1 (Accession P04629), corresponding to amino acid residues around phosphorylated Tyr680 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816213 |
Product Specific Information
Antibody detects endogenous levels of TrkA only when phosphorylated at Tyrosine 680 and Tyrosine 681.
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor family crucial for the development and maintenance of the mammalian nervous system.
TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
Its presence leads to cell differentiation and may specify sensory neuron subtypes.
Mutations in TrkA are associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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