Thermo Fisher Scientific Phospho-Glucocorticoid Receptor (Ser203) Polyclonal Antibody
Glucocorticoid Receptor의 Ser203 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 고순도 액상 형태로 연구용에 적합.
- 카탈로그번호
- PA5104736
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human NR3C1 (Accession P04150), corresponding to amino acid residues around phosphorylated Ser203 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816209 |
Product Specific Information
This antibody detects endogenous levels of NR3C1 only when phosphorylated at Serine 203.
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that acts as both a transcription factor and a regulator of other transcription factors. It forms heteromeric cytoplasmic complexes with heat shock factors and immunophilins and translocates to the nucleus upon ligand binding.
The receptor is expressed in various heart tissues including atria, ventricles, aorta, apex, septum, and atrioventricular node in both adult and fetal stages.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms. Mutations in NR3C1 can lead to glucocorticoid resistance. The receptor binds steroids such as dexamethasone with nanomolar affinity and requires chaperone protein complexes for activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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