Thermo Fisher Scientific Phospho-Glucocorticoid Receptor (Ser203) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of NR3C1 only when phosphorylated at Serine 203.

Target Information

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that acts as both a transcription factor and a regulator of other transcription factors. It forms heteromeric cytoplasmic complexes with heat shock factors and immunophilins and translocates to the nucleus upon ligand binding.
The receptor is expressed in various heart tissues including atria, ventricles, aorta, apex, septum, and atrioventricular node in both adult and fetal stages.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms. Mutations in NR3C1 can lead to glucocorticoid resistance. The receptor binds steroids such as dexamethasone with nanomolar affinity and requires chaperone protein complexes for activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.