Thermo Fisher Scientific BRCA1 Monoclonal Antibody (OTI7B12), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7 K MWCO, 0.5 mL, Product #89882).

Target Information

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and acts as a tumor suppressor. It forms part of the BASC (BRCA1-associated genome surveillance complex) and interacts with RNA polymerase II and histone deacetylase complexes. BRCA1 plays critical roles in transcription, DNA double-strand break repair, and recombination.
Mutations in the BRCA1 gene account for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing influences BRCA1 localization and function, and several disease-associated transcript variants have been identified. A related pseudogene is located on chromosome 17.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.