Thermo Fisher Scientific KIR2DS5 Polyclonal Antibody
Thermo Fisher Scientific의 KIR2DS5 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제된 고순도(>95%) 항체로, 34 kDa의 내인성 단백질을 검출합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human CD158G |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553942 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 34 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by cytoplasmic domain length (L or S).
- Long cytoplasmic domain (L): Transduces inhibitory signals via ITIM motif.
- Short cytoplasmic domain (S): Associates with TYRO protein tyrosine kinase binding protein to transduce activating signals.
Ligands for several KIR proteins are subsets of HLA class I molecules, indicating their role in immune response regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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