Thermo Fisher Scientific MPZ Polyclonal Antibody
Thermo Fisher Scientific의 MPZ Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 MPZ 단백질을 검출하기 위한 토끼 유래 IgG 항체입니다. Western blot과 면역세포염색에 적합하며, 고순도(>95%)로 정제되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in human MPZ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2553943 |
Product Specific Information
- This antibody detects endogenous MPZ protein at a molecular weight of 28–35 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Zero, also known as myelin protein zero (MPZ), is a Type I integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath to ensure stable synaptic transmission.
MPZ constitutes approximately 50% of total protein in the myelin sheath, contributing to structural integrity of peripheral myelin.
It guides compact myelin wrapping through glycine zipper packing interface-dependent dimer and tetramer formation.
Mutations (e.g., G134R) can disrupt multimer formation and cause demyelinating neuropathies such as Charcot-Marie-Tooth disease.
The cytoplasmic domain undergoes serine and tyrosine phosphorylation, which is prevalent during peak nerve myelination.
MPZ transcript is moderately expressed in brain, abundant in thymus, and most abundant in white matter of the CNS.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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