Thermo Fisher Scientific NUMBL Polyclonal Antibody
NUMBL 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체로, 인간 시료에 반응합니다. Western blot 및 Peptide ELISA에 적합하며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 신경발생 연구 및 NF-κB 신호 조절 관련 연구에 활용 가능합니다.
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Thermo Fisher Scientific NUMBL Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 0.5–1 µg/mL
Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence SRSAAASGGPRRPE-C (aa 2–15) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932733 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
NUMBL plays a role in neurogenesis. It is required throughout embryonic neurogenesis to maintain neural progenitor cells (radial glial cells, RGCs) by allowing their daughter cells to choose progenitor over neuronal fate. It is not required for proliferation of neural progenitor cells before embryonic neurogenesis onset. Postnatally, it regulates SVZ neuroblast survival and ependymal wall integrity. NUMBL acts as a negative regulator of NF-kappa-B signaling pathway by preventing MAP3K7IP2 interaction with polyubiquitin chains of TRAF6 and RIPK1, and by promoting Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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