Thermo Fisher Scientific beta Tubulin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:100–1:2,000
• Publications: Refer to Thermo Fisher database

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200
• Publications: Refer to Thermo Fisher database

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat, mouse, zebrafish, and Xenopus.
• Specificity: Tubulin beta chain.

Target Information

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize to form microtubules.

• Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance, and maintenance.
• Mutations in the beta tubulin gene cause congenital fibrosis of the extraocular muscles type 3.
• Beta-III tubulin is also detected in Sertoli cells and transiently in non-neuronal embryonic tissues.
• Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, inhibiting incorporation into microtubules.
• Microtubules play key roles in chromosome segregation, intracellular transport, and cytoskeletal support.
• Beta-tubulin is widely used as a loading control in protein detection assays such as Western blotting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: OST00306W-150UL_beta_Tubulin_P07437-1_Rabbit.svg, OST00306W-150UL_beta_Tubulin_P07437-1_Rabbit_PDP.jpeg)