Thermo Fisher Scientific TRPM4 Polyclonal Antibody
TRPM4 단백질을 인식하는 Rabbit Polyclonal 항체로, Mouse 및 Rat 시료에 반응합니다. Western blot 및 IHC(P) 등 다양한 응용에 사용 가능하며, 합성 펩타이드 항원으로 제작되었습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific TRPM4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse TRPM4 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat.
Specificity: TRPM4.
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. Activated by increased intracellular Ca²⁺ but impermeable to it.
Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization.
Plays a central role in cardiomyocytes, neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells, and more.
Participates in T-cell activation by modulating Ca²⁺ oscillations required for NFAT-dependent IL2 production.
Involved in myogenic constriction of cerebral arteries and insulin secretion control in pancreatic beta-cells.
May contribute to pacemaking or irregular electrical activity under Ca²⁺ overload.
Affects Th1 and Th2 cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization.
Enhances cell proliferation via up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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