Thermo Fisher Scientific TRPV1 Polyclonal Antibody
TRPV1 단백질을 인식하는 Thermo Fisher의 염소 유래 polyclonal 항체로, WB 및 IHC에 사용 가능. 인간 및 기니피그 반응성. 동결건조 형태로 제공되며, 4°C 또는 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Guinea pig, Human |
| Published Species | Not Applicable |
| Host / Isotype | Goat / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 4th cytoplasmic loop of human TRPV1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in guinea pig.
- Specificity: TRPV1.
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1)
TRPV1 is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. It is a non-selective cation channel related to TRP family members such as TRPC3 and TRPC6 and is permeable to calcium, magnesium, sodium, and potassium ions.
Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains. It is activated by noxious heat and functions as a transducer of painful thermal stimuli in vivo. TRPV1 mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons. Expression is mainly limited to sensory ganglia neurons. Four transcript variants differing in the 5′ UTR have been described.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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