Thermo Fisher Scientific Human G-CSF Recombinant Protein, PeproTech
인간 G-CSF 재조합 단백질로, 중성구 및 단핵구의 증식과 활성화를 유도하는 사이토카인 연구용 시약입니다. E. coli 발현 시스템에서 생산되며 ≥98% 순도, <1 EU/µg 엔도톡신 수준을 보장합니다. 세포 증식 분석 및 ELISA 등 다양한 실험에 적합합니다.
- 카탈로그번호
- 300-23-xxx (7개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
7개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human G-CSF Recombinant Protein, PeproTech
Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
- View 1 publication
ELISA
- Tested Dilution: Assay-dependent
- View 1 publication
Functional Assay
- Tested Dilution: Assay-dependent
In vitro Assay (IV)
Miscellaneous PubMed
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse, Non-human primate, Plant, Virus |
| Expression System | E. coli |
| Amino acid sequence | TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP |
| Molecular weight | 18.7 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | <1 EU/µg |
| Activity | ED50 ≤ 0.1 ng/ml (≥ 1 x 10^7 units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
Recombinant Human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
G-CSF (Granulocyte Colony Stimulating Factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes.
Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.
This pleiotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells. It exerts specific effects on the proliferation, differentiation, and activation of hematopoietic cells.
G-CSF is expressed by various transformed cells such as carcinoma and myeloblastic leukemia cells. It is encoded by two distinct DNA sequences, resulting in a full-size, high-activity isoform and a shorter, low-activity isoform.
Highly conserved among species, G-CSF functions through interaction with its receptor on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.
Clinical applications include treatment of neonatal infections, acute myocardial infarction, granulocyte transfusion in neutropenia, severe infections and sepsis, chronic autoimmune neutropenia, acute myeloid leukemia, Sweet’s syndrome, and AIDS.
G-CSF also serves as a marker for various carcinomas such as bladder cancer, and dysfunction is linked to Kostmann Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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