Thermo Fisher Scientific RORB Polyclonal Antibody
RORB 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. IHC(P)에서 5 µg/mL로 검증됨. 다양한 종에 반응하며 PBS 내 0.1% sodium azide 포함. 항원 친화 크로마토그래피로 정제된 액상 항체로, 신경계 연구에 적합.
- 카탈로그번호
- PA534160
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Chicken, Horse, Hamster, Human, Mouse, Non-human primate, Sheep, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from ligand-binding domain of human ROR Beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551513 |
Target Information
Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility.
ROR beta binds to monomeric response elements containing the sequence AnnTAGGTCA as a monomer.
An alternatively spliced isoform, ROR beta2, has been isolated from rats, and its expression is confined to the pineal gland and retina.
ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but has a distinct amino-terminal domain.
ROR beta expression has been documented in various regions of the mouse brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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