Thermo Fisher Scientific ISG15 Recombinant Rabbit Monoclonal Antibody (1H9L21)
ISG15 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로 높은 특이성과 재현성을 제공합니다. Western blot 및 면역형광 등 다양한 응용에 적합하며, 동결 및 장기 보관 시 안정성을 유지합니다. 동물 유래 성분이 없는 포뮬레이션으로 일관된 품질을 보장합니다.
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Thermo Fisher Scientific ISG15 Recombinant Rabbit Monoclonal Antibody (1H9L21)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:100 | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1H9L21 |
| Immunogen | Protein corresponding to mouse ISG15 [aa2-aa155] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784563 |
Available Conjugated Formats
Product Specific Information
This antibody is predicted to react with Rat and Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection, either via conjugation to target proteins (ISGylation) or as a free protein.
It is secreted from monocytes in response to type I interferons and promotes NK-cell proliferation and non-MHC-restricted cytotoxicity.
ISG15 synthesis is induced by IFN-α, IFN-β, or IFN-ω, and by overexpression of interferon regulatory factors or influenza B virus.
It functions intracellularly as a ubiquitin homolog, and mutations can cause Immunodeficiency 38 (IMD38) with basal ganglia calcification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: 703132_ISG15_Q64339-1_Rabbit.svg, 703132_ISG15_Q64339-1_Rabbit_PDP.jpeg)
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