Thermo Fisher Scientific KIAA1524 Monoclonal Antibody (OTI2A1), TrueMAB
인간 KIAA1524(CIP2A) 단백질을 인식하는 마우스 단클론 항체입니다. Western blot에 최적화되어 있으며, 동결건조 형태로 제공됩니다. 1 mg/mL 농도로 재구성 가능하며, PBS 버퍼(8% 트레할로스)로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 635–905 of human KIAA1524 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CIP2A (Cancerous Inhibitor of PP2A) inhibits protein phosphatase 2A (PP2A) activity, which is essential for human cell transformation. It interacts with the oncogenic transcription factor c-Myc, inhibiting PP2A-mediated dephosphorylation at serine 62, thereby preventing c-Myc degradation.
CIP2A overexpression stabilizes c-Myc, promotes anchorage-independent growth, and enhances tumor formation. It is notably overexpressed in head and neck squamous cell carcinoma (HNSCC) and colon cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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