Thermo Fisher Scientific CDK1 Recombinant Rabbit Monoclonal Antibody (SM01-44)
CDK1 단백질을 인식하는 재조합 토끼 모노클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 높은 특이성과 민감도, 로트 간 일관성 보장. 단백질 A로 정제된 액상 항체로 연구용에 적합.
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Thermo Fisher Scientific CDK1 Recombinant Rabbit Monoclonal Antibody (SM01-44)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SM01-44 |
| Immunogen | Synthetic peptide within Human CDK1 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809387 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening individual clones to select optimal candidates.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis. CDK1 acts as a catalytic subunit of the M-Phase Promoting Factor, a universal protein kinase complex among eukaryotes that induces entry into mitosis.
Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays apoptosis onset.
Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(해당 항체의 면역원 구조 이미지, 파일명: MA5-32094_CDK1_P06493-1_Rabbit.svg 및 MA5-32094_CDK1_P06493-1_Rabbit_PDP.jpeg)
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