Thermo Fisher Scientific HJURP Recombinant Rabbit Monoclonal Antibody (16H6L17)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

16H6L17

Immunogen

Proteins corresponding to human HJURP [1) aa47-aa177 2)aa394-aa748] if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HJURP,uniProtId:Q8NCD3-1,ncbiNodeId:9606,antigenRange:47-177|394-748,antigenLength:748,antigenImageFileName:703460_HJURP_Q8NCD3-1_Rabbit.svg,antigenImageFileNamePDP:703460_HJURP_Q8NCD3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2809238

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Cat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Holliday junction recognition protein (HJURP) is a centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. It acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. HJURP prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. It directly binds to Holliday junctions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.