Thermo Fisher Scientific RARA Monoclonal Antibody (OTI2C3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements upon ligand binding (all-trans or 9-cis retinoic acid) and regulate gene expression in various biological processes.
The RXR/RAR heterodimers bind to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites (DR1–DR5).
In the absence of ligand, RXR-RAR heterodimers associate with transcriptional corepressors that promote histone acetylation, chromatin condensation, and transcriptional suppression.
Upon ligand binding, corepressors dissociate and coactivators are recruited, leading to transcriptional activation.
RARA plays an essential role in retinoic acid-induced germ cell development during spermatogenesis, supports early spermatocyte survival, and contributes to skeletal growth and matrix homeostasis in conjunction with RARG. It regulates gene expression in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5 and mediates retinoic acid-induced granulopoiesis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.