Thermo Fisher Scientific NCOA4 Monoclonal Antibody (OTI2F3), TrueMAB
Human NCOA4 단백질(aa 280-553)을 항원으로 제작된 Mouse IgG1 단클론 항체. Western blot에 최적화(1:2,000 희석). Lyophilized 형태로 제공되며 PBS/trehalose buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F3 |
| Immunogen | Human recombinant protein fragment (aa 280–553 of human NCOA4) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Androgen receptor (AR) coactivator ARA70, also known as NCOA4, RFG, and ELE1, is a co-activator that enhances androgen receptor activity.
In human thyroid carcinomas, ARA70 fuses with the Ret proto-oncogene to form Ret/PTC3.
ARA70 exists in two isoforms: ARA70a (widely expressed, highest in testis and adipose tissue) and ARA70b (expressed only in testis).
ARA70a can act as a ligand-enhanced co-activator of PPARγ in adipocytes and may be involved in prostate and ovarian cancer development.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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