Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI5B5), TrueMAB
LPIN1 단백질을 인식하는 마우스 IgG1 단클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공됩니다. 지방 대사 및 인슐린 감수성 관련 연구용으로 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–274 of human LPIN1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The Lipin family of nuclear proteins consists of Lipin-1, Lipin-2, and Lipin-3, all containing a nuclear signal sequence, a conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It activates pathways related to fatty acid oxidation and mitochondrial oxidative phosphorylation through PPARA induction, while suppressing lipogenesis and circulating lipid levels.
LPIN1 abundance promotes fat accumulation and insulin sensitivity, whereas deficiency can lead to insulin resistance and lipodystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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