Thermo Fisher Scientific ZEB2 Monoclonal Antibody (OTI1E12), TrueMAB
인간 ZEB2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB 및 IHC(P) 적용 가능. 무보존제 동결건조 형태이며, 1 mg/mL 농도로 제공. 핵 내 DNA 결합 전사 억제 단백질 ZEB2 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ZEB2, also known as Smad-interacting protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs.
Similar to ZEB1, it inhibits E-cadherin transcription and induces epithelial-mesenchymal transition (EMT), which regulates cell migration during embryonic development and wound healing.
ZEB2 may also protect cells from DNA damage-induced apoptosis, contributing to tumor progression.
It has been observed in the cytoplasm of various cancer tissues, suggesting regulated localization in normal and tumor cells.
Mutations in ZEB2 are associated with Hirschsprung disease and Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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