Thermo Fisher Scientific ZEB2 Monoclonal Antibody (OTI3D8), TrueMAB
ZEB2 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 형태로 제공됩니다. 재구성 후 약 1 mg/mL 농도로 사용 가능하며, 보존제 미함유 상태로 -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ZEB2, also known as Smad-interacting protein 1, is a DNA-binding transcriptional repressor located in the nucleus. It interacts with activated SMADs and inhibits transcription of the E-cadherin gene, inducing epithelial-mesenchymal transition (EMT), which regulates cell migration during embryonic development and wound healing.
ZEB2 can protect cells from DNA damage-induced apoptosis, potentially contributing to tumor progression. It is frequently observed in the cytoplasm of various cancer tissues, suggesting regulated localization in normal and tumor cells. Mutations in ZEB2 are associated with Hirschsprung disease and Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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