Thermo Fisher Scientific ZEB2 Monoclonal Antibody (OTI3D8), TrueMAB

Applications

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ZEB2, also known as Smad-interacting protein 1, is a DNA-binding transcriptional repressor located in the nucleus. It interacts with activated SMADs and inhibits transcription of the E-cadherin gene, inducing epithelial-mesenchymal transition (EMT), which regulates cell migration during embryonic development and wound healing.
ZEB2 can protect cells from DNA damage-induced apoptosis, potentially contributing to tumor progression. It is frequently observed in the cytoplasm of various cancer tissues, suggesting regulated localization in normal and tumor cells. Mutations in ZEB2 are associated with Hirschsprung disease and Mowat-Wilson syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.