Thermo Fisher Scientific JARID1B Polyclonal Antibody
JARID1B(KDM5B) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP에 사용 가능. 고농도(1 mg/mL) 액상 형태로 제공되며 4°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific JARID1B Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1494 and 1544 of human Jumonji, AT rich interactive domain 1B (KDM5B, UniProt ID: Q9UGL1-1, NCBI Node ID: 9606) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
KDM5B is a histone demethylase that specifically demethylates Lys-4 of histone H3, playing a central role in the histone code. It does not demethylate histone H3 Lys-9 or Lys-27. KDM5B acts as a transcriptional corepressor for FOXG1B and PAX9, promoting proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor in melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: A301-813A-M_KDM5B_Q9UGL1-1_Rabbit.svg, A301-813A-M_KDM5B_Q9UGL1-1_Rabbit_PDP.jpeg)
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