Thermo Fisher Scientific TRIP12 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TRIP12 protein. Validated for Western blot and immunoprecipitation. Suitable for detection of E3 ubiquitin ligase involved in DNA repair regulation. Supplied as liquid, 0.2 mg/mL, stored at 4°C. For research...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000–1:25,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 75 and 125 of Human thyroid hormone receptor interactor 12 (TRIP12, UniProt ID: Q14669-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
TRIP12 is an E3 ubiquitin-protein ligase involved in the ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. It mediates ubiquitination of proteins at their N-terminus, independent of lysine residues. In normal cells, TRIP12 targets isoform p19ARF/ARF of CDKN2A for degradation, regulating p53 activation. In cancer cells, compartmental separation prevents this degradation. TRIP12 also ubiquitinates NAE1 and SMARCE1, leading to their degradation. Its activity is modulated by interactions with proteins such as MYC, TRADD, and SMARCC1. TRIP12 acts as a suppressor of RNF168, preventing excessive accumulation of ubiquitinated histones at DNA damage sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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