Thermo Fisher Scientific CDCA8 Polyclonal Antibody
CDCA8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용에 적합. 인간 및 설치류 등 여러 종에 반응하며, 세포 분열 관련 연구에 활용 가능. 고순도 Affinity 정제 및 안정적 PBS/glycerol 저장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CDCA8 (Accession Q53HL2), amino acid residues M1–V32 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851727 |
Product Specific Information
Antibody detects endogenous levels of total CDCA8.
Target Information
CDCA8 is a component of the chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The CPC, including Survivin, CDCA8, INCENP, and Aurora-B, plays crucial roles during mitosis and cell division. CDCA8 interaction with Aurora-B, INCENP, and Survivin increases during G2/M phase and decreases after exit from M phase. It is cell cycle regulated, down-regulated in response to p53/Rb signaling, and up-regulated in many cancer tissues. In Drosophila, inactivation of CDCA8 results in polyploidy, delayed mitosis, and abnormal tissue development. CDCA8 is essential for cell proliferation during early embryonic development, and its aberrant expression is linked to poor prognosis in gastric cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-102318_CDCA8_Q53HL2-1_Rabbit.svg, PA5-102318_CDCA8_Q53HL2-1_Rabbit_PDP.jpeg)
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