Thermo Fisher Scientific POLR1C Polyclonal Antibody
POLR1C 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC에 적합하며, 액상 형태로 1 mg/mL 농도를 유지합니다. PBS 기반 버퍼에 50% glycerol과 0.02% sodium azide를 포함하며, -20°C에서 보관합니다.
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- PA5102312
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human POLR1C, corresponding to a region within C-terminal amino acids |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851721 |
Product Specific Information
This antibody detects endogenous levels of total POLR1C.
Target Information
RNA polymerases transcribe nuclear genes for ribosomal RNA, playing a key role in ribosomal biogenesis.
RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes encoding large ribosomal RNA.
Different subunits of the Pol I transcription machinery respond to various physiological stimuli, indicating involvement of multiple signaling pathways in Pol I transcription.
RPA16, RPA40, and RPA135 are Pol I subunits that associate early in RNA Pol I assembly.
RPA40 is essential for the function and integrity of the complex and also serves as a critical subunit of RNA polymerase III (Pol III).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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